Parrella Paola

Nel periodo dal 1998 al 2001 svolge l'attività di ricerca post dottorato presso la Johns Hopkins University School of Medicine di Baltimore in USA, indagando gli aspetti genetici delle neoplasie. Negli anni seguenti ha implementato nella attività di ricerca condotta nuove strategie per lo studio delle alterazioni del programma epigenetico nei tumori solidi. Come Responsabile di progetti di ricerca ha condotto diversi studi anche in collaborazione con Istituti italiani ed esteri, con efficace gestione ed impiego di fondi e di risorse.

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Informazioni aggiuntive

  • Pubblicazioni Scientifiche:

    Totale pubblicazioni a partire dal 2011: 35


    Anno

    2019; 20(12):

    Can Epigenetics of Endothelial Dysfunction Represent the Key to Precision Medicine in Type 2 Diabetes Mellitus?

    Coco C, Sgarra L, Potenza MA, Nacci C, Pasculli B, Barbano R, Parrella P, Montagnani M


    2019; 21(1): 20

    MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors.

    Schwarzenbacher D, Klec C, Pasculli B, Cerk S, Rinner B, Karbiener M, Ivan C, Barbano R, Ling H, Wulf-Goldenberg A, Stanzer S, Rinnerthaler G, Stoeger H, Bauernhofer T, Haybaeck J, Hoefler G, Jahn SW, Parrella P, Calin GA, Pichler M


    2018; 12(9): 937-940

    The value of epigenetic biomarkers in breast cancer.

    Parrella P


    2018; ():

    Epigenetics of breast cancer: Biology and clinical implication in the era of precision medicine.

    Pasculli B, Barbano R, Parrella P


    Epigenetic mechanisms in cancer: predictive value of epigenetic Signatures 2017; 3: 275-311

    Epigenetic mechanisms in cancer: predictive value of epigenetic Signatures

    Pasculli B., Barbano R., Parrella P.

    2017; 7(): 45283

    Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients.

    Barbano R, Pasculli B, Rendina M, Fontana A, Fusilli C, Copetti M, Castellana S, Valori VM, Morritti M, Graziano P, Luigi C, Coco M, Picardo F, Mazza T, Evron E, Murgo R, Maiello E, Esteller M, Fazio VM, Parrella P


    2016; (): 0

    BRAF V600E mutation in metastatic colorectal cancer: methods of detection and correlation with clinical and pathologic features.

    Roma C, Rachiglio AM, Pasquale R, Fenizia F, Iannaccone A, Tatangelo F, Antinolfi G, Parrella P, Graziano P, Sabatino L, Colantuoni V, Botti G, Maiello E, Normanno N


    64 Congresso Nazionale SINCH 24_26 Giugno 2016 Napoli 2015; :

    Ruolo dello stato di metilazione del gene KEAP1 nella prognosi dei gliomi maligni.

    Icolaro N., PArrella P., Barbano R., Muscarella L., Barbara P., Copetti M., Catapano D., Fazio V.M., d'Angelo V.

    64 Congresso Nazionale SINCH Napoli 24_26 Giugno 2016 2015; :

    Identificazione di un pannello di miRNA associato al ?Fenotipo Aggressivo? ed alla prognosi dei gliomi.

    Icolaro N., Parrella P., Barbano R., Palumbo O., Pasculli B., Copetti M., Carella M., Fazio V.M., D'Angelo V.

    2015; :

    Competitive allele-specific TaqMan PCR (Cast-PCR) is a sensitive, specific and fast method for BRAF V600 mutation detection in Melanoma patients.

    Barbano R., Pasculli B., Coco M., Fontana A., Copetti M., Rendina M., Valori V.M., Graziano P., Maiello E., Fazio V.M., Parrella P.


    2015; 105(): 274-288

    Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme.

    Sestito S, Nesi G, Daniele S, Martelli A, Digiacomo M, Borghini A, Pietra D, Calderone V, Lapucci A, Falasca M, Parrella P, Notarangelo A, Breschi MC, Macchia M, Martini C, Rapposelli S


    2015; 15(): 470

    TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival.

    Micale L, Fusco C, Fontana A, Barbano R, Augello B, De Nittis P, Copetti M, Pellico MT, Mandriani B, Cocciadiferro D, Parrella P, Fazio VM, Dimitri LM, D'Angelo V, Novielli C, Larizza L, Daga A, Merla G


    2014; 9(10): e108950

    A MiRNA Signature for Defining Aggressive Phenotype and Prognosis in Gliomas.

    Barbano R, Palumbo O, Pasculli B, Galasso M, Volinia S, D'Angelo V, Icolaro N, Coco M, Dimitri L, Graziano P, Copetti M, Valori VM, Maiello E, Carella M, Fazio VM, Parrella P


    2014; 13(): 142

    Evaluation of microRNA-10b prognostic significance in a prospective cohort of breast cancer patients.

    Parrella P, Barbano R, Pasculli B, Fontana A, Copetti M, Valori VM, Poeta ML, Perrone G, Righi D, Castelvetere M, Coco M, Balsamo T, Morritti M, Pellegrini F, Onetti-Muda A, Maiello E, Murgo R, Fazio VM


    2013; ():

    Establishment and genetic characterization of ANGM-CSS, a novel, immortal cell line derived from a human glioblastoma multiforme.

    Notarangelo A, Trombetta D, D'Angelo V., Parrella P, Palumbo O, Storlazzi CT, Impera L, Muscarella LA, La Torre A, Affuso A, Fazio VM, Carella M, Zelante L


    2013; 73(1): 50-8

    Molecular Dissection of the VHL Gene in Solitary Capillary Hemangioblastoma of the Central Nervous System.

    Muscarella LA, la Torre A, Faienza A, Catapano D, Bisceglia M, D'Angelo V, Parrella P, Coco M, Fini G, Tancredi A, Zelante L, Fazio VM, D'Agruma L


    2013; 14(1): S161

    P1* A MIRNA SIGNATURE FOR DEFINING AGGRESSIVE PHENOTYPE AND PROGNOSIS IN GLIOMAS

    Pasculli B., Barbano R., Palumbo O., Galasso M., Volinia S., D'Angelo V., Coco M., Dimitri L., Copetti M., Valori V.M., Maiello E., Carella M., Fazio V.M., Parrella P.

    2013; 14(1): S111

    H43 a novel rare EGFR mutation in Exon 18 showed stable disease after TKI treatment

    Muscarella L.A., Parrella P., Nanni L., Di Micco C., Dimitri L.,Coco M., la Torre A., Barbano R., Maiello E., Fazio V.M.

    2013; 14(1): S128

    L27 MIRNA-10B as putative predictive marker of metastases development and survival for breast cancer patients

    Barbano R., Pasculli B., Valori V.M., Fontana A., Copetti M., Poeta M.L., Perrone G., Pellegrini F., Onetti-Muda A., Murgo R., Maiello E., Fazio V.M., Parrella P.

    2013; 5(10): 1523-36

    The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation.

    Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, Kuchnio A, Farace MG, Fazio VM, Piacentini M, De Strooper B, Achsel T, Neri G, Neven P, Evans DG,


    2013; 12(7): 1058-70

    Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma.

    Brait M, Munari E, Lebron C, Noordhuis MG, Begum S, Michailidi C, Gonzalez-Roibon N, Maldonado L, Sen T, Guerrero-Preston R, Cope L, Parrella P, Fazio VM, Ha PK, Netto GJ, Sidransky D, Hoque MO


    2013; 28(2): e208-15

    VHL gene alterations in Italian patients with isolated renal cell carcinomas.

    Muscarella LA, D'Agruma L, la Torre A, Gigante M, Coco M, Parrella P, Battaglia M, Carrieri G, Carella M, Leopoldo Z, Fazio VM, Loreto G, Elena R, Torre AL


    XIV National Congress of Medical Oncology 2012; Roma 27/29 ottobre 2012: D48

    Gene expression analysis of somatostatin receptors in peripheral blood of small cell lung cancer affected patients and association with tumour imaging with octreoscan

    D'Alessandro V, la Torre A, Muscarella LA, Copetti M, Parrella P, Tancredi A, Boragine R, Pellegrini F, La Viola M, Maiello E, Mazzoccoli G, Frusciante V, Vendemiale G, Fazio VM

    2012; 8(1):

    Aberrant keap1 methylation in breast cancer and association with clinicopathological features.

    Barbano R, Muscarella LA, Pasculli B, Valori VM, Fontana A, Coco M, la Torre A, Balsamo T, Poeta ML, Marangi GF, Maiello E, Castelvetere M, Pellegrini F, Murgo R, Fazio VM, Parrella P


    2012; 27(4): e389-94

    Aberrant genes promoter methylation in neural crest-derived tumors.

    la Torre A, Muscarella LA, Parrella P, Balsamo T, Bisceglia M, Valori VM, la Torre A, Barbano R, Perrella E, Poeta ML, Melchionda G, Merla G, Maiello E, Pellicano R, Fazio VM


    2012; 25(3): 691-702

    Hormone and cytokine circadian alteration in non-small cell lung cancer patients.

    Mazzoccoli G, Sothern RB, Francavilla M, Giuliani F, Carughi S, Muscarella LA, Fazio VM, Parrella P, Vinciguerra M, Tarquini R


    2012; 51(12): 1133-43

    Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.

    Poeta ML, Massi E, Parrella P, Pellegrini P, De Robertis M, Copetti M, Rabitti C, Perrone G, Muda AO, Molinari F, Zanellato E, Crippa S, Caputo D, Caricato M, Frattini M, Coppola R, Fazio VM


    2011; :

    Abstract D39 - XIII Congresso Nazionale di Oncologia Medica, Bologna 2011

    Muscarella LA et al.

    2011; :

    Abstract A25 - XIII Congresso Nazionale di Oncologia Medica, Bologna 2011

    Latiano TP et al.

    2011; ():

    Comparison of circadian characteristics for cytotoxic lymphocyte subsets in non-small cell lung cancer patients versus controls.

    Mazzoccoli G, Sothern RB, Parrella P, Muscarella LA, Fazio VM, Giuliani F, Polyakova V, Kvetnoy IM


    2011; 79(5-6): 415-22

    Cetuximab plus FOLFOX-4 in untreated patients with advanced colorectal cancer: a Gruppo Oncologico dell'Italia Meridionale Multicenter phase II study.

    Colucci G, Giuliani F, Garufi C, Mattioli R, Manzione L, Russo A, Lopez M, Parrella P, Tommasi S, Copetti M, Daniele B, Pisconti S, Tuveri G, Silvestris N, Maiello E


    2011; 129(3): 536-45

    High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.

    Barbano R, Copetti M, Perrone G, Pazienza V, Muscarella LA, Balsamo T, Storlazzi CT, Ripoli M, Rinaldi M, Valori VM, Latiano TP, Maiello E, Stanziale P, Carella M, Mangia A, Pellegrini F, Bisceglia M, Muda AO, Altomare V, Murgo R, Fazio VM, Parrella P


    2011; 6(6):

    Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer.

    Muscarella LA, Parrella P, D'Alessandro V, la Torre A, Barbano R, Fontana A, Tancredi A, Guarnieri V, Balsamo T, Coco M, Copetti M, Pellegrini F, De Bonis P, Bisceglia M, Scaramuzzi G, Maiello E, Valori VM, Merla G, Vendemiale G, Fazio VM


    2011; ():

    Gene expression of somatostatin receptor subtypes SSTR2a, SSTR3 and SSTR5 in peripheral blood of neuroendocrine lung cancer affected patients.

    Muscarella LA, D'Alessandro V, la Torre A, Copetti M, De Cata A, Parrella P, Sperandeo M, Pellegrini F, Frusciante V, Maiello E, Merla G, Fazio VM, Vendemiale G


    2011; 6(3): 317-25

    Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome.

    Muscarella LA, Barbano R, D'Angelo V, Copetti M, Coco M, Balsamo T, la Torre A, Notarangelo A, Troiano M, Parisi S, Icolaro N, Catapano D, Valori VM, Pellegrini F, Merla G, Carella M, Fazio VM, Parrella P


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