Muscarella Lucia Anna

Ricercatore senior in Oncologia Molecolare, 2012 SIC/AACR Scholar in training award. Si occupa della caratterizzazione molecolare di marcatori diagnostici e prognostici del tumore del polmone e dell'identificazione di alterazioni genetiche associate allo sviluppo di sindromi tumorali ereditarie. E' attualmente responsabile di due progetti di ricerca triennali finanziati dall'AIRC e dal Ministero della Salute Italiano finalizzati allo studio di marcatori molecolari di resistenza alla chemioterapia nei pazienti affetti da tumore del polmone.

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Informazioni aggiuntive

  • Pubblicazioni Scientifiche:

    Totale pubblicazioni a partire dal 2011: 56


    Anno

    2019; 20(11):

    Methylation Density Pattern of KEAP1 Gene in Lung Cancer Cell Lines Detected by Quantitative Methylation Specific PCR and Pyrosequencing.

    Fabrizio FP, Sparaneo A, Centra F, Trombetta D, Storlazzi CT, Graziano P, Maiello E, Fazio VM, Muscarella LA


    2019; 20(10):

    Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.

    Sparaneo A, Fabrizio FP, la Torre A, Graziano P, Di Maio M, Fontana A, Bisceglia M, Rossi A, Pizzolitto S, De Maglio G, Tancredi A, Grimaldi F, Balsamo T, Centra F, Manzorra MC, Trombetta D, Pantalone A, Bonfitto A, Maiello E, Fazio VM, Muscarella LA


    2018; 10(): 1758835918815598

    Gene code CD274/PD-L1: from molecular basis toward cancer immunotherapy.

    Fabrizio FP, Trombetta D, Rossi A, Sparaneo A, Castellana S, Muscarella LA


    2018; 2018(): 2492063

    Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs.

    Fabrizio FP, Sparaneo A, Trombetta D, Muscarella LA


    2018; 214(8): 1156-1165

    Extraneuraxial hemangioblastoma: A clinicopathologic study of 10 cases with molecular analysis of the VHL gene.

    Muscarella LA, Bisceglia M, Galliani CA, Zidar N, Ben-Dor DJ, Pasquinelli G, la Torre A, Sparaneo A, Fanburg-Smith JC, Lamovec J, Michal M, Bacchi CE


    2018; 9(29): 20721-20733

    Large deletion at the CDC73 gene locus and search for predictive markers of the presence of a CDC73 genetic lesion.

    Muscarella LA, Turchetti D, Fontana A, Baorda F, Palumbo O, la Torre A, de Martino D, Franco R, Losito NS, Repaci A, Pagotto U, Cinque L, Copetti M, Chiofalo MG, Pezzullo L, Graziano P, Scillitani A, Guarnieri V


    2018; :

    Frequent NRG1 fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression.

    Trombetta D, Graziano P, Scarpa A, Sparaneo A, Rossi G, Rossi A, Di Maio M, Antonello D, Mafficini A, Fabrizio FP, Manzorra CM, Balsamo T, Centra F, Simbolo M, Pantalone A, Notarangelo M, Parente P, Dimitri MCL, Bonfitto A, Fiordelisi F, Storlazzi CT, L'A


    2017; ():

    Extraneuraxial Hemangioblastoma: Clinicopathologic Features and Review of the Literature.

    Bisceglia M, Muscarella LA, Galliani CA, Zidar N, Ben-Dor D, Pasquinelli G, la Torre A, Sparaneo A, Fanburg-Smith JC, Lamovec J, Michal M, Bacchi CE


    2017; ():

    Pharmacokinetic drug evaluation of osimertinib for the treatment of non-small cell lung cancer.

    Rossi A M D, Muscarella LA Ph D, Di Micco C M D, Carbonelli C M D, D'Alessandro V M D, Notarangelo S M D, Palomba G M D, Sanpaolo G M D, Taurchini M M D, Graziano P M D, Maiello E M D


    2017; 12(10): e161-e163

    ALK and NRG1 Fusions Coexist in a Patient with Signet Ring Cell Lung Adenocarcinoma.

    Muscarella LA, Trombetta D, Fabrizio FP, Scarpa A, Fazio VM, Maiello E, Rossi A, Graziano P


    2017; ():

    NRG1-ErbB lost in translation: a new paradigm for lung cancer?

    Trombetta D, Rossi A, Fabrizio FP, Sparaneo A, Graziano P, Fazio VM, Muscarella LA


    2017; ():

    Alterations of DNA methylation in parathyroid tumors.

    Guarnieri V, Muscarella LA, Verdelli C, Corbetta S


    2017; 13(2): 593-598

    A malignant inflammatory myofibroblastic tumor of the hypopharynx harboring the 3a/b variants of the EML4-ALK fusion gene.

    Muscarella LA, Rossi G, Trombetta D, La Torre A, Di Candia L, Mengoli MC, Sparaneo A, Fazio VM, Graziano P


    2017; 168(6): 1086-1100.e10

    Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

    Lim AI, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella LA, Rogge L, Norel X, Sallenave JM, Allez M,


    2017; ():

    Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.

    Fabrizio FP, Costantini M, Copetti M, la Torre A, Sparaneo A, Fontana A, Poeta L, Gallucci M, Sentinelli S, Graziano P, Parente P, Pompeo V, De Salvo L, Simone G, Papalia R, Picardo F, Balsamo T, Flammia GP, Trombetta D, Pantalone A, Kok K, Paranita F, Mu


    2016; :

    Keap1/Nrf2 impairing revised: are we missing the single nucleotide polymorphisms?

    Muscarella L., Fazio V.M.


    2016; ():

    BRAF mutations in sarcomatoid and large cell carcinoma of the lung.

    Mengoli MC, Bettelli S, Gasparri P, Bertolini F, Barbieri F, Spaltro AA, Manfredini S, Muscarella LA, Graziano P


    2016; :

    A malignant inflammatory myofibroblastic tumor of the hypopharynx harboring the 3a/b variants of the EML4-ALK fusion gene

    Muscarella L., Rossi G., Trombetta D., La Torre A., Di Candia L., Mengoli M.C., Sparaneo A., Fazio V.M., Graziano P.

    The American Journal of Pathology 2016; 186 suppl: S12

    Keap1/Nrf2 Pathway In Kidney Cancer: Frequent Methylation of Keap1 Gene Promoter In Clear Renal Cell Carcinoma

    Fabrizio F., Costantini M., Copetti M., la Torre A., Sparaneo A., Fontana A., Poeta M., Gallucci M., Sentinelli S., Graziano P., Parente P., Pompeo V., De Salvo L., Simone G., Papalia R., Picardo F., Balsamo T., Flammia G.P., Trombetta D., Pantalone A., K

    2016; 2016(): 7316492

    Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad.

    Sparaneo A, Fabrizio FP, Muscarella LA


    2016; 6(): 31549

    Gene expression of muscular and neuronal pathways is cooperatively dysregulated in patients with idiopathic achalasia.

    Palmieri O, Mazza T, Merla A, Fusilli C, Cuttitta A, Martino G, Latiano T, Corritore G, Bossa F, Palumbo O, Muscarella LA, Carella M, Graziano P, Andriulli A, Latiano A


    Lung Cancer Management 2016; :

    Liquid biopsy and NSCLC

    Trombetta D., Sparaneo A., Fabrizio F.P., Muscarella L.

    2016; ():

    EZH2 and ZFX oncogenes in malignant behaviour of parathyroid neoplasms.

    Sanpaolo E, Miroballo M, Corbetta S, Verdelli C, Baorda F, Balsamo T, Graziano P, Fabrizio FP, Cinque L, Scillitani A, Muscarella LA, Guarnieri V


    64 Congresso Nazionale SINCH 24_26 Giugno 2016 Napoli 2015; :

    Ruolo dello stato di metilazione del gene KEAP1 nella prognosi dei gliomi maligni.

    Icolaro N., PArrella P., Barbano R., Muscarella L., Barbara P., Copetti M., Catapano D., Fazio V.M., d'Angelo V.

    2015; 77(6): 481-5

    The Post-Surgical Long-Term Behaviour of Lung Carcinoid Tumours.

    Tancredi A, Muscarella LA, la Torre A, Scaramuzzi R, Valori VM, Fazio VM, Scaramuzzi G


    2015; :

    The post surgical long term behaviour of lung carcinoid tumors

    Tancredi A., Muscarella L.A., La Torre A., Scaramuzzi R., Valori V.M., Fazio V.M., Scaramuzzi G.

    2015; 524(7563): 47-53

    Comprehensive genomic profiles of small cell lung cancer.

    George J, Lim JS, Jang SJ, Cun Y, Ozretic L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelman


    2014; 14(): 396

    FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities.

    L'Abbate A, Lo Cunsolo C, Macrì E, Iuzzolino P, Mecucci C, Doglioni C, Coco M, Muscarella LA, Salati S, Tagliafico E, Minoia C, De Tullio G, Guarini A, Testoni N, Agostinelli C, Storlazzi CT


    2014; 4(4): 415-22

    CD74-NRG1 Fusions in Lung Adenocarcinoma.

    Fernandez-Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, Daßler J, Malchers F, Schöttle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, Brambilla E, Nagy-Mignotte H, Moro-S


    2013; ():

    Establishment and genetic characterization of ANGM-CSS, a novel, immortal cell line derived from a human glioblastoma multiforme.

    Notarangelo A, Trombetta D, D'Angelo V., Parrella P, Palumbo O, Storlazzi CT, Impera L, Muscarella LA, La Torre A, Affuso A, Fazio VM, Carella M, Zelante L


    2013; 73(1): 50-8

    Molecular Dissection of the VHL Gene in Solitary Capillary Hemangioblastoma of the Central Nervous System.

    Muscarella LA, la Torre A, Faienza A, Catapano D, Bisceglia M, D'Angelo V, Parrella P, Coco M, Fini G, Tancredi A, Zelante L, Fazio VM, D'Agruma L


    2013; 8(12): e82292

    Identification and Functional Characterization of Three NoLS (Nucleolar Localisation Signals) Mutations of the CDC73 Gene

    Pazienza V, la Torre A, Baorda F, Alfarano M, Chetta M, Muscarella LA, Battista C, Copetti M, Kotzot D, Kapelari K, Al-Abdulrazzaq D, Perlman K, Sochett E, Cole DE, Pellegrini F, Canaff L, Hendy GN, D'Agruma L, Zelante L, Carella M, Scillitani A, Guarnier


    2013; 5(209): 209ra153

    A genomics-based classification of human lung tumors.

    Clinical Lung Cancer Genome Project (CLCGP), Network Genomic Medicine (NGM)


    2013; 31(32): 4140-7

    A prognostic DNA methylation signature for stage I non-small-cell lung cancer.

    Sandoval J, Mendez-Gonzalez J, Nadal E, Chen G, Carmona FJ, Sayols S, Moran S, Heyn H, Vizoso M, Gomez A, Sanchez-Cespedes M, Assenov Y, Müller F, Bock C, Taron M, Mora J, Muscarella LA, Liloglou T, Davies M, Pollan M, Pajares MJ, Torre W, Montuenga LM, B


    2013; 5 (209ra153): 1-13

    A Genomics-Based Classification of Human Lung Tumors

    The Clinical Lung Cancer Genome Project (CLCGP) and Network Genomic Medicine (NGM)


    2013; 14(1): S111

    H43 a novel rare EGFR mutation in Exon 18 showed stable disease after TKI treatment

    Muscarella L.A., Parrella P., Nanni L., Di Micco C., Dimitri L.,Coco M., la Torre A., Barbano R., Maiello E., Fazio V.M.

    2013; 28(2): e208-15

    VHL gene alterations in Italian patients with isolated renal cell carcinomas.

    Muscarella LA, D'Agruma L, la Torre A, Gigante M, Coco M, Parrella P, Battaglia M, Carrieri G, Carella M, Leopoldo Z, Fazio VM, Loreto G, Elena R, Torre AL


    XIV National Congress of Medical Oncology 2012; Roma 27/29 ottobre 2012: D48

    Gene expression analysis of somatostatin receptors in peripheral blood of small cell lung cancer affected patients and association with tumour imaging with octreoscan

    D'Alessandro V, la Torre A, Muscarella LA, Copetti M, Parrella P, Tancredi A, Boragine R, Pellegrini F, La Viola M, Maiello E, Mazzoccoli G, Frusciante V, Vendemiale G, Fazio VM

    2012; 8(1):

    Aberrant keap1 methylation in breast cancer and association with clinicopathological features.

    Barbano R, Muscarella LA, Pasculli B, Valori VM, Fontana A, Coco M, la Torre A, Balsamo T, Poeta ML, Marangi GF, Maiello E, Castelvetere M, Pellegrini F, Murgo R, Fazio VM, Parrella P


    2012; 44(10): 1104-10

    Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

    Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S,


    2012; 27(4): e389-94

    Aberrant genes promoter methylation in neural crest-derived tumors.

    la Torre A, Muscarella LA, Parrella P, Balsamo T, Bisceglia M, Valori VM, la Torre A, Barbano R, Perrella E, Poeta ML, Melchionda G, Merla G, Maiello E, Pellicano R, Fazio VM


    2012; 35(6): 411-22

    CDC73 mutations and parafibromin immunohistochemistry in parathyroid tumors: clinical correlations in a single-centre patient cohort.

    Guarnieri V, Battista C, Muscarella LA, Bisceglia M, de Martino D, Baorda F, Maiello E, D'Agruma L, Chiodini I, Clemente C, Minisola S, Romagnoli E, Corbetta S, Viti R, Eller-Vainicher C, Spada A, Iacobellis M, Malavolta N, Carella M, Canaff L, Hendy GN,


    2012; 25(3): 691-702

    Hormone and cytokine circadian alteration in non-small cell lung cancer patients.

    Mazzoccoli G, Sothern RB, Francavilla M, Giuliani F, Carughi S, Muscarella LA, Fazio VM, Parrella P, Vinciguerra M, Tarquini R


    2011; ():

    A rare S33C mutation of CTNNB1 encoding ß-catenin in a parathyroid adenoma found in an Italian primary hyperparathyroid cohort.

    Guarnieri V, Baorda F, Battista C, Bisceglia M, Balsamo T, Gruppioni E, Fiorentino M, Muscarella LA, Coco M, Barbano R, Corbetta S, Spada A, Cole DE, Canaff L, Hendy GN, Carella M, Scillitani A


    2011; :

    Abstract D39 - XIII Congresso Nazionale di Oncologia Medica, Bologna 2011

    Muscarella LA et al.

    2011; ():

    Comparison of circadian characteristics for cytotoxic lymphocyte subsets in non-small cell lung cancer patients versus controls.

    Mazzoccoli G, Sothern RB, Parrella P, Muscarella LA, Fazio VM, Giuliani F, Polyakova V, Kvetnoy IM


    2011; ():

    Alteration of Hypothalamic-Pituitary-Thyroid Axis Function in Non-Small-Cell Lung Cancer Patients.

    Mazzoccoli G, Pazienza V, Piepoli A, Muscarella LA, Giuliani F, Sothern RB


    Biomedicine & Aging Pathology 2011; 1: 129-137

    Chronobiologic study of neuro-endocrine axis hormone sequence signalling in healthy men

    Mazzoccoli G, Sothern RB, Pazienza V, Piepoli A, Muscarella LA, Dagostino MP, Giuliani F

    2011; ():

    Circadian Aspects of Growth Hormone-Insulin-Like Growth Factor Axis Function in Patients With Lung Cancer.

    Mazzoccoli G, Sothern RB, Pazienza V, Piepoli A, Muscarella LA, Giuliani F, Tarquini R


    2011; 129(3): 536-45

    High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.

    Barbano R, Copetti M, Perrone G, Pazienza V, Muscarella LA, Balsamo T, Storlazzi CT, Ripoli M, Rinaldi M, Valori VM, Latiano TP, Maiello E, Stanziale P, Carella M, Mangia A, Pellegrini F, Bisceglia M, Muda AO, Altomare V, Murgo R, Fazio VM, Parrella P


    2011; ():

    Antiphase signalling in the neuroendocrine-immune system in healthy humans.

    Mazzoccoli G, Muscarella LA, Fazio VM, Piepoli A, Pazienza V, Dagostino MP, Giuliani F, Polyakova VO, Kvetnoy I


    2011; 40(3): 481-5

    Coexistence of multiple endocrine neoplasia type 1 and type 2 in a large Italian family.

    Mastroianno S, Torlontano M, Scillitani A, D'Aloiso L, Verrienti A, Bonfitto N, De Bonis A, D'Agruma L, Muscarella LA, Guarnieri V, Dicembrino F, Maranghi M, Durante C, Filetti S


    Biomedicine & Aging Pathology 2011; 1: 39-45

    Age-related changes of GH-IGF1 axis function

    Mazzoccoli G, Inglese M, Dagostinoa MP, Piepoli A, Muscarella LA, Pazienza V, Tarquini R, Giuliani F

    2011; 6(6):

    Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer.

    Muscarella LA, Parrella P, D'Alessandro V, la Torre A, Barbano R, Fontana A, Tancredi A, Guarnieri V, Balsamo T, Coco M, Copetti M, Pellegrini F, De Bonis P, Bisceglia M, Scaramuzzi G, Maiello E, Valori VM, Merla G, Vendemiale G, Fazio VM


    2011; ():

    Gene expression of somatostatin receptor subtypes SSTR2a, SSTR3 and SSTR5 in peripheral blood of neuroendocrine lung cancer affected patients.

    Muscarella LA, D'Alessandro V, la Torre A, Copetti M, De Cata A, Parrella P, Sperandeo M, Pellegrini F, Frusciante V, Maiello E, Merla G, Fazio VM, Vendemiale G


    2011; 6(3): 317-25

    Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome.

    Muscarella LA, Barbano R, D'Angelo V, Copetti M, Coco M, Balsamo T, la Torre A, Notarangelo A, Troiano M, Parisi S, Icolaro N, Catapano D, Valori VM, Pellegrini F, Merla G, Carella M, Fazio VM, Parrella P


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