IRCCS Casa Sollievo della Sofferrenza opera di San Pio da Pietrelcina

UPTA – Unità Produttiva per Terapie Avanzate, è un’officina farmaceutica ai sensi del Decreto legislativo 219/2006 (Direttiva 2001/83/CE). L’Unità ha ricevuto, da parte dell’Agenzia Italiana del Farmaco, l’autorizzazione a produrre prodotti medicinali a base di cellule staminali neurali per sperimentazioni cliniche (aM 118/2019).

UPTA si occupa inoltre di condurre attività di ricerca su cellule staminali neurali per lo sviluppo di nuove strategie terapeutiche per patologie neurodegenerative.

Patologie studiate: Sclerosi Laterale Amiotrofica, Sclerosi Multipla

Anno di Avvio: 2020
Durata: 2025
Ente Finanziatore: Associazione Italiana per la Ricerca sul Cancro (AIRC)
Project Leader: Vincenzo Giambra
Principal Investigator: Vincenzo Giambra

Anno di Avvio: 2020
Durata: 2023
Ente Finanziatore: Worldwide Cancer Research
Project Leader: Vincenzo Giambra
Principal Investigator: Vincenzo Giambra

Anno di Avvio: 2018
Durata: 2022
Ente Finanziatore: Ministero della Salute della Repubblica Italiana
Project Leader: Vincenzo Giambra
Principal Investigator: Vincenzo Giambra

Totale pubblicazioni a partire dal 2011: n. 31

Elenco pubblicazioni: 

1. Sansico F, Miroballo M, Bianco DS, Tamiro F, Colucci M, Santis E, Rossi G, Rosati J, Di Mauro L, Miscio G, Mazza T, Vescovi AL, Mazzoccoli G, Giambra V*, On Behalf Of Css-Covid Group.
   COVID-19 Specific Immune Markers Revealed by Single Cell Phenotypic Profiling.
   Biomedicines. 2021 Nov 29;9(12):1794. PMID: 34944610
2. Colucci M, De Santis E, Totti B, Miroballo M, Tamiro F, Rossi G, Piepoli A, De Vincentis G, Greco A, Mangia A, Cianci R, Di Mauro L, Miscio G, Giambra V* Associations between Allelic Variants of the Human IgH 3' Regulatory Region 1 and the Immune
   Response to BNT162b2 mRNA Vaccine.
   Vaccines (Basel). 2021 Oct 19;9(10):1207. PMID: 34696315
3. K Bhanumathy K, Balagopal A, Vizeacoumar FS, Vizeacoumar FJ, Freywald A, Giambra V*
   Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia
   Cancers (Basel). 7;13(2):184. (2021) - PMID: 33430292 Review
4. Tamiro F, Weng AP, Giambra V*
   Targeting Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia
   Cancer Res. 2021 Jan 7. (2021) - PMID: 33414170 Review
5. Giambra V*, Gusscott S, Gracias D, Song R, Lam SH, Panelli P, Tyshchenko K,Jenkins CR, Hood C, Lorzadeh A, Carles A, Hirst M, Eaves CJ, Weng AP*
   Epigenetic restoration of fetal-like IGF1 signaling inhibits leukemia stem cell activity
   Cell Stem Cell, 2018 Nov 1. PMID: 30269902
6. Belmonte M, Hoofd C, Weng AP and Giambra V*,
   Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?,
   Current Oncology, Vol 23, No 1 (2016) (Review)
7. Hoofd C, Wang X, Lam SH, Jenkins C, Wood B, Giambra V* and Weng AP**,
   CD44 promotes chemoresistance in T-ALL by increased drug efflux,
   Experimental Hematology, 2015 Dec 1. PMID:26708679
8. Giambra V*, Jenkins C, Lam SH, Hoofd C, Belmonte M, Wang X, Gusscott S, Gracias D, and Weng AP*,
   Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling,
   Blood, 2015 May 1. PMID: 25934477
9. Montesano C**, Giambra V**, Frezza D, Palma P, Castelli-Gattinara G, Mattei M, Mancino G, Colizzi V, and Amicosante M,
   HS1,2 Ig enhancer alleles association to AIDS progression in a paediatric cohort infected with a monophyletic HIV-strain,
   BMRI Infectious Diseases, 2014;2014:637523 (2014) - PMID 25009819; PMCID: PMC4055013.
10. Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries KR, Eaves C, and Weng AP,
    Notch1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-Θ and reactive oxygen species,
    Nature Medicine, 18, 1693-1698 (2012) - PMID:23086478; PMCID: PMC3738873.
11. Mangia A, Piazzolla V, Cocomazzi G, Ciciriello V, Giambra V, Antinucci S, Maiorana A, Giuliani F, Montomoli E, Cantaloni P, Manenti A, Serra N
    Cellular and humoral immune responses and breakthrough infections after two doses of BNT162b vaccine in healthcare workers (HW) 180 days after the second vaccine shot
    Frontiers in Public Health - in press
12. Cocomazzi G, Piazzolla V, Squillante M,Antinucci S, Giambra V, Giuliani F, Maiorana A, Serra N, Mangia A
    Early Serological Response to BNT162b2 mRNA Vaccine in Healthcare Workers.
    Vaccines (Basel). 2021 Aug 16;9(8):913. PMID: 34452038
13. Carbone A, De Santis E, Cela O, Giambra V, Miele L, Marrone G, Grieco A, Buschbeck M, Capitanio N, Mazza T, Mazzoccoli G
    The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro
    Model of Hepatocellular Carcinoma.
    Biomedicines. 2021 Aug 20;9(8):1057. PMID: 34440260
14. Rossi G, Giambra V, de Waure C, Giacchetta I, Minervini MM, Abbenante MC, Spadano R, La Torre A, Scalzulli PR, Cascavilla N
    Log reduction of leukemic cells and minimal residual disease by flow cytometry represent effective predictors of clinical outcome in elderly patients with acute myeloid leukemia.
    Cytometry B Clin Cytom. 2022 Jan;102(1):26-33. PMID: 33983682
15. Grandone E, Tiscia G, Pesavento R, De Laurenzo A, Ceccato D, Sartori MT, Mirabella L, Cinnella G, Mastroianno M, Dalfino L, Colaizzo D, Vettor R, Intrieri M, Ostuni A, Margaglione M; CSS- COVID Use of low-molecular weight heparin, transfusion and mortality in COVID-19 patients not requiring ventilation.
    J Thromb Thrombolysis. 2021 Oct;52(3):772-778. PMID: 33844150
16. Micale L, Morlino S, Biagini T, Carbone A, Fusco C, Ritelli M, Giambra V, Zoppi N, Nardella G, Notarangelo A, Schirizzi A, Mazzoccoli G, Grammatico P, Wade EM, Mazza T, Colombi M, Castori M
    Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A > G variant alters the TGFβ-mediated α-SMA cytoskeleton assembly and autophagy
    Biochim Biophys Acta Mol Basis Dis. 1;1866(6):165742. (2020) - PMID: 32105826
17. Frezza D, Martinez-Labarga C, Giambra V, Serone E, Scano G, Rickards O, D'Addabbo P, Novelletto A
    Concerted variation of the 3' regulatory region of Ig heavy chain and Gm haplotypes across human continental populations
    Am J Phys Anthropol. 171(4):671-682. (2020) – PMID: 31957883
18. Venuto S, Monteonofrio L, Cozzolino F, Monti M, Appolloni I, Mazza T, Canetti D, Giambra V, Panelli P, Fusco C, Squeo GM, Croce AI, Pucci P, Malatesta P, Soddu S, Merla G, Micale L
    TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability
    Cancer Lett. 31;473:98-106. (2020) – PMID: 31904480
19. Grasselli C, Carbone A, Panelli P, Giambra V, Bossi M, Mazzoccoli G, De Filippis L
    Neural Stem Cells from Shank3-ko Mouse Model Autism Spectrum Disorders
    Mol Neurobiol. 57(3):1502-1515. (2020) – PMID: 31773410
20. Rossi G, Giambra V, Minervini MM, De Waure C, Mancinelli S, Ciavarella M, Sinisi NP, Scalzulli PR, Carella AM, Cascavilla N
    Leukemia-associated immunophenotypes subdivided in "categories of specificity" improve the sensitivity of minimal residual disease in predicting relapse in acute myeloid leukemia
    Cytometry B Clin Cytom. 98(3):216-225. (2020) – PMID: 31697027
21. Gusscott S, Tamiro F, Giambra V, Weng AP
    Insulin-like growth factor (IGF) signaling in T-cell acute lymphoblastic leukemia
    Adv Biol Regul. 74:100652. (2019) - PMID: 31543360 Review
22. Morlino S, Carbone A, Ritelli M, Fusco C, Giambra V, Nardella G, Notarangelo A, Panelli P, Mazzoccoli G, Zoppi N, Grammatico P, Wade EM, Colombi M, Castori M, Micale L
    TAB2 c.1398dup variant leads to haploinsufficiency and impairs extracellular matrix homeostasis
    Hum Mutat. 40(10):1886-1898. (2019) - PMID: 31250519
23. Rossi G, Falcone AP, Minervini MM, De Cillis GP, De Waure C, Sisti LG, Giambra V, Valente D, Chiello V, Scalzulli PR, Carella AM and Cascavilla N
    Minimal residual disease and log-reduction of plasma cells are associated with superior response after double autologous stem cell transplant in younger patients with multiple myeloma
    Cytometry B Clin Cytom. 2019 May;96(3) – PMID: 30549231
24. Jenkins CE, Gusscott S, Wong RJ, Shevchuk OO, Rana G, Giambra V, Tyshchenko K, Islam R, Hirst M, Weng AP
    RUNX1 promotes cell growth in human T-cell acute lymphoblastic leukemia by transcriptional regulation of key target genes
    Exp Hematol. Aug;64:84-96, (2018) - PMID: 29733873
25. Gusscott S, Jenkins CE, Lam SH, Giambra V, Pollak M, and Weng AP,
    Molecular determinants of IGF dependence in human T-cell acute lymphoblastic leukemia,
    Plos ONE, 2016 Aug 17;11(8):e0161158 - PMID: 27532210
26. Sette M, D'Addabbo P, Kelly G, Cicconi A, Micheli E, Cacchione S, Poma A, Gargioli C, Giambra V, Frezza D.
    Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3' regulatory regions and its conservation in mammals.
    Biopolymers, 2016 Nov;105(11):768-78. PMID: 27287611
27. Serone E, Daleno C, Principi N, Poretti L, Iacoacci V, Gargioli C, Magrini A, Massoud R, D’Addabbo P, Cattalini M, Giambra V, Plebani A, Esposito S, and Frezza D,
    The change in Ig regulation from child to adults disconnects the correlation with the 3'RR hs1.2 polymorphism,
    BMC Immunol, 2014 Nov 13;15:45 (2014) – PMID:25391515.
28. Napolioni V, Serone E, Iacoacci V, Carpi MC, Giambra V, and Frezza D,
    The functional VNTR of IGH enhancer HS1.2 associates with human longevity and interacts with TNFA promoter diplotype in a population of Central Italy,
    Gene, Aug 28 (2014) - PMID: 25175451.
29. Jenkins CR, Shevchuk OO, Giambra V, Lam SH, Carboni JM, Gottardis MM, Holzenberger M, Pollak M, Humphries RK, and Weng AP,
    IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein,
    Exp Hematol, 40, 715-723 (2012) - PMID: 22613471.
30. Frezza D, Serone E, Lolli S, Cianci R, D’Addabbo P, Mattioli C, Giambra V, Pavlovic N, Djordjevic V, Pandolfi F, and Kostic E,
    Balkan Endemic Nephropathy risk is associated to the HS1.2 Ig enhancer polymorphism,
    Eur. J. Inflamat, 10, 393-403 (2012).
31. Frezza D, Tolusso B, Giambra V, Gremese E, Nowik M, Mattioli M, Serone E, Canestri S, Petricca L, D’Antona G, Birshtein B K, and Ferraccioli G,
    Polymorphisms of IgH enhancer HS1.2 and risk of Systemic Lupus Erythematosus,
    Ann Rheum Dis, 71, 1309-15 (2012) - PMID: 22294636.

*corresponding author

**contributed equally to this work